Suppression of Neuroinflammation Attenuates Persistent Cognitive and Neurogenic Deficits in a Rat Model of Cardiopulmonary Bypass

Wang, Yi and Machizawa, Maro G. and Lisle, Turner and Williams, Cedric L. and Clarke, Ryon and Anzivino, Matthew and Kron, Irving and Lee, Kevin S. (2022) Suppression of Neuroinflammation Attenuates Persistent Cognitive and Neurogenic Deficits in a Rat Model of Cardiopulmonary Bypass. Frontiers in Cellular Neuroscience, 16. ISSN 1662-5102

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Abstract

Post-operative cognitive dysfunction (POCD) can be a serious surgical complication, and patients undergoing cardiac procedures are at particular risk for POCD. This study examined the effect of blocking neuroinflammation on behavioral and neurogenic deficits produced in a rat model of cardiopulmonary bypass (CPB). Minocycline, a drug with established anti-inflammatory activity, or saline was administered daily for 30 days post-CPB. Treatment with minocycline reduced the number of activated microglia/macrophages observed in the dentate gyrus of the hippocampus at 6 months post-CPB, consistent with an anti-inflammatory action in this CPB model. Behavioral testing was conducted at 6 months post-CPB utilizing a win-shift task on an 8-arm radial maze. Minocycline-treated animals performed significantly better than saline-treated animals on this task after CPB. In addition, the CPB-induced reduction in adult neurogenesis was attenuated in the minocycline-treated animals. Together, these findings indicate that suppressing neuroinflammation during the early post-surgical phase can limit long-term deficits in both behavioral and neurogenic outcomes after CPB.

Item Type: Article
Subjects: Grantha Library > Medical Science
Depositing User: Unnamed user with email support@granthalibrary.com
Date Deposited: 17 Apr 2023 06:44
Last Modified: 23 Sep 2024 04:18
URI: http://asian.universityeprint.com/id/eprint/557

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